Background: Colorectal cancer is an emerging problem in cystic fibrosis (CF). The goal of this study was to evaluate adenoma detection by systematic colonoscopic screening and surveillance.
Methods: We analyzed prospectively collected results of colonoscopies initiated at age 40years from 88 CF patients at a single Cystic Fibrosis Center. We also reviewed results of diagnostic colonoscopies from 27 patients aged 30-39years performed during the same time period at the Center.
Results: The incidence of polyp detection increased markedly after age 40 in CF patients. Greater than 50% were found to have adenomatous polyps; approximately 25% had advanced adenomas as defined by size and/or histopathology; 3% were found to have colon cancer. Multivariate analysis demonstrated specific risk factors for adenoma formation and progression.
Conclusions: Early screening and more frequent surveillance should be considered in patients with CF due to early incidence and progression of adenomas in this patient population.
Keywords: Adenoma; Colon cancer; Colorectal cancer screening; Cystic fibrosis.
Copyright © 2016 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.