Mediator Architecture and RNA Polymerase II Interaction

J Mol Biol. 2016 Jun 19;428(12):2569-2574. doi: 10.1016/j.jmb.2016.01.028. Epub 2016 Feb 3.


Integrated structural biology recently elucidated the architecture of Mediator and its position on RNA polymerase II. Here we summarize these achievements and list open questions on Mediator structure and mechanism.

Keywords: RNA polymerase II; coactivator; gene transcription; multiprotein complex.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Humans
  • Mediator Complex / metabolism*
  • RNA Polymerase II / metabolism*
  • Transcription, Genetic / physiology
  • Transcriptional Activation / physiology


  • Mediator Complex
  • RNA Polymerase II