The core of hepatitis C virus pathogenesis

Curr Opin Virol. 2016 Apr;17:66-73. doi: 10.1016/j.coviro.2016.01.009. Epub 2016 Feb 3.

Abstract

Capsid proteins form protective shells around viral genomes and mediate viral entry. However, many capsid proteins have additional and important roles for virus infection and in modulating cellular response to infection, with important consequences on pathogenesis. Infection by the Hepatitis C virus (HCV) can lead to liver steatosis, cirrhosis, and hepatocellular carcinoma. Herein, we focus on the role in pathogenesis of Core, the capsid protein of the HCV.

Publication types

  • Review

MeSH terms

  • Animals
  • Capsid Proteins / genetics
  • Capsid Proteins / immunology
  • Capsid Proteins / metabolism*
  • Carcinoma, Hepatocellular / virology
  • Genome, Viral
  • Hepacivirus / genetics
  • Hepacivirus / immunology
  • Hepacivirus / pathogenicity*
  • Hepatitis C / virology*
  • Humans
  • Liver Cirrhosis / virology
  • Liver Neoplasms / virology
  • Mice
  • Viral Core Proteins / chemistry
  • Viral Core Proteins / genetics
  • Viral Core Proteins / metabolism*

Substances

  • Capsid Proteins
  • Viral Core Proteins