Physician-pharmacist collaboration versus usual care for treatment-resistant hypertension

J Am Soc Hypertens. 2016 Apr;10(4):307-17. doi: 10.1016/j.jash.2016.01.010. Epub 2016 Jan 18.


Team-based care has been recommended for patients with treatment-resistant hypertension (TRH), but its efficacy in this setting is unknown. We compared a physician-pharmacist collaborative model (PPCM) to usual care in patients with TRH participating in the Collaboration Among Pharmacists and Physicians To Improve Outcomes Now study. At baseline, 169 patients (27% of Collaboration Among Pharmacists and Physicians To Improve Outcomes Now patients) had TRH: 111 received the PPCM intervention and 58 received usual care. Baseline characteristics were similar between treatment arms. After 9 months, adjusted mean systolic blood pressure was reduced by 7 mm Hg more with PPCM intervention than usual care (P = .036). Blood pressure control was 34.2% with PPCM versus 25.9% with usual care (adjusted odds ratio, 1.92; 95% confidence interval, 0.33-11.2). These findings suggest that team-based care in the primary care setting may be effective for TRH. Additional research is needed regarding the long-term impact of these models and to identify patients most likely to benefit from team-based interventions.

Keywords: Collaborative care; hypertension; pharmacist; treatment-resistant hypertension.

Publication types

  • Comparative Study
  • Multicenter Study
  • Randomized Controlled Trial
  • Research Support, N.I.H., Extramural

MeSH terms

  • Aged
  • Antihypertensive Agents / therapeutic use*
  • Blood Pressure Determination
  • Coronary Vasospasm / drug therapy*
  • Female
  • Humans
  • Hypertension / drug therapy*
  • Intersectoral Collaboration*
  • Male
  • Middle Aged
  • Patient Care Team*
  • Pharmacists
  • Physicians
  • Primary Health Care / methods*
  • Prospective Studies
  • Treatment Outcome


  • Antihypertensive Agents

Supplementary concepts

  • Hypertension Resistant to Conventional Therapy