Technology, Applications, and Process Challenges of Dual Chamber Systems

J Pharm Sci. 2016 Jan;105(1):4-9. doi: 10.1016/j.xphs.2015.11.025. Epub 2016 Jan 13.


Dual-chamber systems provide an option as a drug and device combination product, when home care and emergency lyophilized products are intended. Nevertheless, until today, there are only a few products on the market, due to the challenges and limitations in manufacturability, product formulation, and product stability in a dual-chamber configuration, as well as economic considerations. This review serves to describe currently available dual-chamber systems and to discuss factors to be considered for appropriate selection and establishing fill-finish processes.

Keywords: aseptic processing; biologics; biopharmaceutical; dual-chamber cartridge; dual-chamber syringe; dual-chamber systems; fixed dose combination; freeze-drying; home care; small volume parenterals.

Publication types

  • Review

MeSH terms

  • Equipment Design
  • Freeze Drying / instrumentation*
  • Freeze Drying / methods*
  • Proteins / administration & dosage*
  • Proteins / chemistry
  • Syringes
  • Technology, Pharmaceutical / instrumentation*
  • Technology, Pharmaceutical / methods*


  • Proteins