A double-blind, placebo-controlled trial of high doses of gangliosides in amyotrophic lateral sclerosis

Neurology. 1989 Dec;39(12):1635-7. doi: 10.1212/wnl.39.12.1635.


We performed a 3-month, double-blind, placebo-controlled trial of 300 mg of gangliosides (Cronassial) in 40 outpatients with amyotrophic lateral sclerosis (ALS). We evaluated drug effect through physical examinations and symptom scales. Though this dosage had no major toxic effect, Cronassial treatment did not significantly benefit ALS patients.

Publication types

  • Clinical Trial
  • Comparative Study
  • Controlled Clinical Trial

MeSH terms

  • Amyotrophic Lateral Sclerosis / drug therapy*
  • Clinical Trials as Topic
  • Double-Blind Method
  • Drug Administration Schedule
  • Gangliosides / administration & dosage*
  • Gangliosides / adverse effects
  • Gangliosides / therapeutic use
  • Humans
  • Placebos


  • Gangliosides
  • Placebos