Tropheryma whipplei infection and Whipple's disease

Lancet Infect Dis. 2016 Mar;16(3):e13-22. doi: 10.1016/S1473-3099(15)00537-X. Epub 2016 Feb 6.


Recent advances in medical microbiology, epidemiology, cellular biology, and the availability of an expanded set of diagnostic methods such as histopathology, immunohistochemistry, PCR, and bacterial culture have improved our understanding of the clinical range and natural course of Tropheryma whipplei infection and Whipple's disease. Interdisciplinary and transnational research activities have contributed to the clarification of the pathogenesis of the disorder and have enabled controlled trials of different treatment strategies. We summarise the current knowledge and new findings relating to T whipplei infection and Whipple's disease.

Publication types

  • Review

MeSH terms

  • Anti-Bacterial Agents / therapeutic use
  • Humans
  • Immune Reconstitution Inflammatory Syndrome
  • Immunosuppressive Agents / adverse effects
  • Tropheryma*
  • Whipple Disease / diagnosis
  • Whipple Disease / drug therapy
  • Whipple Disease / microbiology*


  • Anti-Bacterial Agents
  • Immunosuppressive Agents