Analysis of delayed TBE-vaccine booster after primary vaccination

J Travel Med. 2016 Feb 8;23(2):tav020. doi: 10.1093/jtm/tav020. Print 2016 Feb.


An open, uncontrolled single centre study was conducted in the Travel Clinic at the Military Hospital, Brussels. Eighty-eight subjects were recruited who had a primary series of tick-borne encephalitis (TBE) vaccine more than 5 years ago and who never received a booster dose afterwards. Response rate after booster vaccination was very high: 84 out of 88 subjects (95.5%) had neutralizing antibodies on plaque reduction neutralization test and all (100%) had IgG antibodies on ELISA, on Day 21-28 after booster vaccination. This study adds valuable information to the common situation of delayed booster interval. The results of our study indicate that in young healthy travellers (<50 years), one booster vaccination after a primary series of TBE vaccine in the past is sufficient to obtain protective antibodies, even if primary vaccination is much longer than the recommended booster interval of 5 years.

Keywords: TBE-vaccine; delayed booster.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Belgium
  • Encephalitis Viruses, Tick-Borne / immunology*
  • Encephalitis, Tick-Borne / prevention & control*
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Hospitals, Military
  • Humans
  • Immunization Schedule
  • Immunization, Secondary*
  • Male
  • Middle Aged
  • Military Medicine
  • Neutralization Tests
  • Outcome Assessment, Health Care*
  • Travel Medicine
  • Viral Vaccines / immunology*


  • Viral Vaccines