Lyme disease: musculoskeletal manifestations

Rheum Dis Clin North Am. 1989 Nov;15(4):649-56.


A previously unrecognized musculoskeletal syndrome led to the recognition of this "new" infectious disease. Several distinct patterns of musculoskeletal involvement can be seen throughout the course of untreated Lyme disease. Diffuse, nonspecific muscle achiness and stiffness can be seen early to be followed by characteristically brief, recurrent episodes of LIMP and transient arthritis that help to differentiate LD from other arthropathies. Chronic oligoarticular arthritis is seen in a few. Lyme arthropathy most closely resembles the reactive arthropathies. In a few cases, LD has mimicked other connective tissue disorders such as juvenile rheumatoid arthritis, rheumatoid arthritis, myositis, and scleroderma. It would appear that the full spectrum of musculoskeletal LD is still being defined.

Publication types

  • Review

MeSH terms

  • Arthritis / diagnosis*
  • Diagnosis, Differential
  • Humans
  • Lyme Disease / diagnosis*
  • Muscular Diseases / diagnosis*
  • Time Factors