Translation regulation via nascent polypeptide-mediated ribosome stalling

Curr Opin Struct Biol. 2016 Apr:37:123-33. doi: 10.1016/ Epub 2016 Feb 7.


As the nascent polypeptide chain is being synthesized, it passes through a tunnel within the large ribosomal subunit. Interaction between the nascent polypeptide chain and the ribosomal tunnel can modulate the translation rate and induce translational stalling to regulate gene expression. In this article, we highlight recent structural insights into how the nascent polypeptide chain, either alone or in cooperation with co-factors, can interact with components of the ribosomal tunnel to regulate translation via inactivating the peptidyltransferase center of the ribosome and inducing ribosome stalling.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Open Reading Frames
  • Peptides / chemistry*
  • Protein Biosynthesis*
  • Ribosomes / chemistry*
  • Viral Envelope Proteins / chemistry


  • Peptides
  • UL4 protein, Human cytomegalovirus
  • Viral Envelope Proteins