Effects of traditional Korean medicine on anti-Müllerian hormone in patients with diminished ovarian reserve: A retrospective study

Complement Ther Med. 2016 Feb:24:118-22. doi: 10.1016/j.ctim.2015.12.005. Epub 2015 Dec 18.


Objective: The purpose of the present study is to retrospectively evaluate the effect of traditional Korean medicine (TKM) on ovarian reserve by measuring serum anti-Müllerian hormone (AMH) levels in patients with diminished ovarian reserve (DOR).

Study design: We performed a retrospective chart review of patients with DOR who had received TKM for at least 2 months and had undergone serum AMH tests before and after TKM treatment. A total of 22 patients with DOR were included in the study.

Results: There were no significant differences in AMH levels before and after TKM in all patients (n=22, p=0.237). However, when the study population was divided into two age groups (<38 (n=12) and ≥38 years (n=10)) to determine whether there was a age-related difference in the effect of TKM with DOR, a significant increase in AMH levels before and after TKM was observed in the age <38 (p<0.05).

Conclusions: TKM may provide an effective option for patients aged <38 years with DOR, but it should be interpreted cautiously as more rigorous research is needed. Further studies in a larger population are needed to confirm these results and to evaluate the effects of improved ovarian reserve on fertility outcomes following TKM in patients with DOR.

Keywords: Anti-Müllerian hormone; Herbal medicine; Infertility; Ovarian reserve; Traditional Korean medicine.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Anti-Mullerian Hormone / blood*
  • Female
  • Humans
  • Infertility, Female / therapy*
  • Medicine, Korean Traditional*
  • Ovarian Reserve / physiology*
  • Retrospective Studies
  • Young Adult


  • Anti-Mullerian Hormone