Plasma adropin level in patients with pseudoexfoliation

Int Ophthalmol. 2016 Oct;36(5):737-42. doi: 10.1007/s10792-016-0185-8. Epub 2016 Feb 10.


The aim of this study was to evaluate plasma adropin levels in patients with pseudoexfoliation (PEX). This retrospective case-control study included 35 patients with PEX and 35 individuals without PEX who served as controls. Plasma adropin levels with triglycerides, total cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL), and haemoglobin A1c (HGBA1C) concentrations were measured in both groups. The mean serum adropin levels were 3.24 ± 0.95 ng/mL (range, 1.90-7.88 ng/mL) in patients with PEX syndrome and 5.78 ± 2.85 ng/mL (range, 2.08-5.41 ng/mL) in PEX glaucoma patients. There was no statistically significant difference in mean adropin levels between PEX syndrome and PEX glaucoma patients. However, similar adropin levels were found in the PEX glaucoma patients and the control group (P > 0.05). The mean serum adropin levels were 3.34 ± 0.89 ng/mL (range, 1.90-5.39 ng/mL) in the PEX group and 5.78 ± 2.85 ng/mL (range, 3.08-11.06 ng/mL) in the control group. The mean serum adropin level of the PEX group was significantly lower than that of the control group (P < 0.001). There were no significant differences between the two groups in terms of serum glucose, total cholesterol, LDL, HDL, HGBA1C, triglycerides levels, or body mass index (all P > 0.05). Adropin level is lower in patients with PEX.

Keywords: Adropin; Glaucoma; Pseudoexfoliation syndrome.

MeSH terms

  • Aged
  • Biomarkers / blood
  • Blood Proteins
  • Case-Control Studies
  • Cholesterol / blood
  • Exfoliation Syndrome / blood*
  • Exfoliation Syndrome / diagnosis
  • Female
  • Glaucoma, Open-Angle / blood*
  • Glaucoma, Open-Angle / diagnosis
  • Glycated Hemoglobin / metabolism
  • Humans
  • Intercellular Signaling Peptides and Proteins
  • Intraocular Pressure
  • Male
  • Middle Aged
  • Peptides / blood*
  • Retrospective Studies


  • Biomarkers
  • Blood Proteins
  • Enho protein, human
  • Glycated Hemoglobin A
  • Intercellular Signaling Peptides and Proteins
  • Peptides
  • hemoglobin A1c protein, human
  • Cholesterol