Peripheral plasma vitamin D and non-HDL cholesterol reflect the severity of cerebral cavernous malformation disease

Biomark Med. 2016;10(3):255-64. doi: 10.2217/bmm.15.118. Epub 2016 Feb 9.


Aim: To correlate cerebral cavernous malformations (CCMs) disease aggressiveness with peripheral blood biomarkers hypothesized mechanistically.

Patients & methods: A prospective case-control study enrolled 43 CCM patients, where 25-(OH) vitamin D, HDL and non-HDL cholesterol, CRP plasma levels and leukocyte ROCK activity were correlated with parameters of disease aggressiveness reflecting chronic and acute domains.

Results: Patients with one or more features of chronically aggressive disease (early age at symptom onset, two or more symptomatic bleeds, high lesion burden) had significantly lower 25-(OH) vitamin D and non-HDL cholesterol levels in comparison to patients without these features.

Conclusion: Validation of these biomarkers and their potential treatment modulation may influence the clinical care of patients with CCM disease.

Keywords: aggressiveness; biomarker; cerebral cavernous malformation; inflammation; non-HDL cholesterol; vitamin D.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acute Disease
  • Adult
  • Biomarkers / blood
  • C-Reactive Protein / metabolism
  • Cholesterol, HDL / blood*
  • Chronic Disease
  • Demography
  • Female
  • Hemangioma, Cavernous, Central Nervous System / blood*
  • Hemangioma, Cavernous, Central Nervous System / pathology*
  • Humans
  • Leukocytes / enzymology
  • Male
  • Middle Aged
  • Vitamin D / blood*
  • rho-Associated Kinases / metabolism


  • Biomarkers
  • Cholesterol, HDL
  • Vitamin D
  • C-Reactive Protein
  • rho-Associated Kinases