Expression of Sox genes in tooth development

Int J Dev Biol. 2015;59(10-12):471-8. doi: 10.1387/ijdb.150192ao.


Members of the Sox gene family play roles in many biological processes including organogenesis. We carried out comparative in situ hybridization analysis of seventeen sox genes (Sox1-14, 17, 18, 21) during murine odontogenesis from the epithelial thickening to the cytodifferentiation stages. Localized expression of five Sox genes (Sox6, 9, 13, 14 and 21) was observed in tooth bud epithelium. Sox13 showed restricted expression in the primary enamel knots. At the early bell stage, three Sox genes (Sox8, 11, 17 and 21) were expressed in pre-ameloblasts, whereas two others (Sox5 and 18) showed expression in odontoblasts. Sox genes thus showed a dynamic spatio-temporal expression during tooth development.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Embryo, Mammalian / cytology
  • Embryo, Mammalian / metabolism*
  • Gene Expression Regulation, Developmental*
  • In Situ Hybridization
  • Mice
  • Mice, Transgenic
  • Odontogenesis / physiology*
  • SOXD Transcription Factors / physiology*
  • Tooth Germ / cytology
  • Tooth Germ / metabolism*


  • SOXD Transcription Factors
  • Sox6 protein, mouse