Botulinum Toxin for the Treatment of Tremor and Tics

Semin Neurol. 2016 Feb;36(1):54-63. doi: 10.1055/s-0035-1571217. Epub 2016 Feb 11.


The therapeutic applications of botulinum toxin (BoNT) have grown manifold since its initial approval in 1989 by the U.S. Food and Drug Administration for the treatment of strabismus, blepharospasm, and other facial spasms. Although it is the most potent biologic toxin known to man, long-term studies have established its safety in the treatment of a variety of neurologic and nonneurologic disorders. Despite a paucity of randomized controlled trials, BoNT has been found to be beneficial in treating a variety of tremors and tics when used by clinicians skilled in the administration of the drug for these hyperkinetic movement disorders. Botulinum toxin injections can provide meaningful improvement in patients with localized tremors and tics; in some cases, they may be an alternative to other treatments with more undesirable adverse effects.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Acetylcholine Release Inhibitors / administration & dosage
  • Animals
  • Botulinum Toxins / administration & dosage*
  • Humans
  • Tics / diagnosis
  • Tics / drug therapy*
  • Tics / physiopathology
  • Treatment Outcome
  • Tremor / diagnosis
  • Tremor / drug therapy*
  • Tremor / physiopathology


  • Acetylcholine Release Inhibitors
  • Botulinum Toxins