The Avian Influenza Virus Polymerase Brings ANP32A Home to Roost

Cell Host Microbe. 2016 Feb 10;19(2):137-8. doi: 10.1016/j.chom.2016.01.013.


Avian influenza virus polymerases function poorly in mammals, restricting transmission across species and the emergence of pandemic outbreaks. Long et al. (2016) have now identified ANP32A as a crucial cellular protein that dictates species-specific polymerase activity.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Animals
  • Avian Proteins / chemistry*
  • Avian Proteins / metabolism*
  • Host Specificity*
  • Humans
  • Influenza A virus / enzymology*
  • Intracellular Signaling Peptides and Proteins / chemistry*
  • Intracellular Signaling Peptides and Proteins / metabolism*
  • RNA-Dependent RNA Polymerase / metabolism*
  • Viral Proteins / metabolism*


  • Avian Proteins
  • Intracellular Signaling Peptides and Proteins
  • Viral Proteins
  • RNA-Dependent RNA Polymerase