Lyme arthritis

Biomed Pharmacother. 1989;43(6):401-3. doi: 10.1016/0753-3322(89)90236-9.


Evanescent arthralgias and myalgias are common early symptoms of Lyme disease. Transient, intermittent episodes of monoarticular, oligoarticular, or sometimes migratory polyarticular arthritis, lasting weeks to months, with disease-free intervals, are frequently observed in untreated patients with erythema chronicum migrans. A minority of patients develop chronic joint involvement, most commonly affecting the knee. Antibiotic therapy given during erythema chronicum migrans is often protective with regard to late joint manifestations. In chronic Lyme arthritis, however, the response to antibiotics is variable.

Publication types

  • Review

MeSH terms

  • Anti-Bacterial Agents / therapeutic use
  • Arthritis, Infectious / etiology*
  • Arthritis, Infectious / prevention & control
  • Borrelia Infections / complications
  • Humans
  • Lyme Disease / complications*
  • Lyme Disease / diagnosis
  • Lyme Disease / drug therapy
  • Serologic Tests
  • Synovitis / etiology


  • Anti-Bacterial Agents