Low-level laser therapy versus 5% amlexanox: a comparison of treatment effects in a cohort of patients with minor aphthous ulcers

Oral Surg Oral Med Oral Pathol Oral Radiol. 2016 Mar;121(3):269-73. doi: 10.1016/j.oooo.2015.11.021. Epub 2015 Dec 19.


Objective: The aim of the study was to compare the treatment effects of 5% amlexanox and low-level laser therapy (LLLT) in a cohort of patients who experienced minor aphthous stomatitis.

Study design: A clinical trial was performed between 2012 and 2014 on 50 participants having minor aphthous ulcers. Group A participants were treated with amlexanox oral paste (lexanox 5% oral paste), and group B participants were treated with LLLT. Pain scores and sizes of ulcers were measured on the first, third, and seventh days of treatment in both groups. Data were analyzed using paired t test and independent t test.

Results: No significant difference was observed between the two groups with respect to pain level on the first and seventh days of treatment.

Conclusions: Both amlexanox and LLLT were equally effective in relieving pain associated with minor aphthous stomatitis. Both groups showed significant reduction in ulcer sizes and in pain scores.

Publication types

  • Clinical Trial
  • Comparative Study

MeSH terms

  • Adolescent
  • Adult
  • Aminopyridines / therapeutic use*
  • Anti-Allergic Agents / therapeutic use*
  • Female
  • Humans
  • India
  • Low-Level Light Therapy*
  • Male
  • Middle Aged
  • Pain Measurement
  • Stomatitis, Aphthous / therapy*
  • Treatment Outcome


  • Aminopyridines
  • Anti-Allergic Agents
  • amlexanox