Children with multiphasic disseminated encephalomyelitis and antibodies to the myelin oligodendrocyte glycoprotein (MOG): Extending the spectrum of MOG antibody positive diseases

Mult Scler. 2016 Dec;22(14):1821-1829. doi: 10.1177/1352458516631038. Epub 2016 Feb 11.


Background: Myelin oligodendrocyte glycoprotein (MOG) antibodies have been described in children with acute disseminated encephalomyelitis (ADEM), recurrent optic neuritis, neuromyelitis optica spectrum disorders and more recently in children with multiphasic disseminated encephalomyelitis (MDEM).

Objective: To delineate the clinical, cerebrospinal fluid (CSF) and radiological features of paediatric MDEM with MOG antibodies.

Methods: Clinical course, serum antibodies, CSF, magnetic resonance imaging (MRI) studies and outcome of paediatric MDEM patients were reviewed.

Results: A total of 8 children with two or more episodes of ADEM were identified from a cohort of 295 children with acute demyelinating events. All children had persisting MOG antibodies (median titre: 1:1280). All ADEM episodes included encephalopathy, polyfocal neurological signs and a typical MRI. Apart from ADEM episodes, three children had further clinical attacks without encephalopathy. Median age at initial presentation was 3 years (range: 1-7 years) and median follow-up 4 years (range: 1-8 years). New ADEM episodes were associated with new neurological signs and new MRI lesions. Clinical outcome did range from normal (four of the eight) to mild or moderate impairment (four of the eight). A total of four children received monthly immunoglobulin treatment during the disease course.

Conclusion: Children with MDEM and persisting MOG antibodies constitute a distinct entity of relapsing demyelinating events and extend the spectrum of MOG antibody-associated diseases.

Keywords: Multiphasic disseminated encephalomyelitis; acquired demyelinating syndromes; acute disseminated encephalomyelitis; children; magnetic resonance imaging; myelin oligodendrocyte glycoprotein.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Autoantibodies / cerebrospinal fluid*
  • Child
  • Child, Preschool
  • Demyelinating Autoimmune Diseases, CNS* / blood
  • Demyelinating Autoimmune Diseases, CNS* / cerebrospinal fluid
  • Demyelinating Autoimmune Diseases, CNS* / diagnostic imaging
  • Demyelinating Autoimmune Diseases, CNS* / physiopathology
  • Encephalomyelitis* / blood
  • Encephalomyelitis* / cerebrospinal fluid
  • Encephalomyelitis* / diagnostic imaging
  • Encephalomyelitis* / physiopathology
  • Female
  • Follow-Up Studies
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Myelin-Oligodendrocyte Glycoprotein / immunology*


  • Autoantibodies
  • MOG protein, human
  • Myelin-Oligodendrocyte Glycoprotein