Hemorrhagic Fever with Renal Syndrome: Pathogenesis and Clinical Picture

Front Cell Infect Microbiol. 2016 Feb 3;6:1. doi: 10.3389/fcimb.2016.00001. eCollection 2016.


Hantaan virus (HTNV) causes hemorrhagic fever with renal syndrome (HFRS), which is a zoonosis endemic in eastern Asia, especially in China. The reservoir host of HTNV is field mouse (Apodemus agraricus). The main manifestation of HFRS, including acute kidney injury, increases vascular permeability, and coagulation abnormalities. In this paper, we review the current knowledge of the pathogenesis of HFRS including virus factor, immunity factor and host genetic factors. Furthermore, the treatment and prevention will be discussed.

Keywords: Bunyavirus; hantaan virus; hantavirus; hemorrhagic fever with renal syndrome; pathogenesis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Antibodies, Viral
  • Antiviral Agents / therapeutic use
  • Asia
  • Endothelial Cells / pathology
  • Endothelial Cells / virology
  • Europe
  • Hantaan virus / immunology*
  • Hemorrhagic Fever with Renal Syndrome / drug therapy
  • Hemorrhagic Fever with Renal Syndrome / pathology*
  • Hemorrhagic Fever with Renal Syndrome / transmission
  • Hemorrhagic Fever with Renal Syndrome / virology
  • Host-Pathogen Interactions / immunology*
  • Humans
  • Immunity, Cellular / immunology*
  • Immunity, Innate / immunology*
  • Kidney / pathology
  • Kidney / virology


  • Antibodies, Viral
  • Antiviral Agents