Cell cycle control in Alphaproteobacteria

Curr Opin Microbiol. 2016 Apr;30:107-113. doi: 10.1016/j.mib.2016.01.010. Epub 2016 Feb 10.


Alphaproteobacteria include many medically and environmentally important organisms. Despite the diversity of their niches and lifestyles, from free-living to host-associated, they usually rely on very similar mechanisms to control their cell cycles. Studies on Caulobacter crescentus still lay the foundation for understanding the molecular details of pathways regulating DNA replication and cell division and coordinating these two processes with other events of the cell cycle. This review highlights recent discoveries on the regulation and the mode of action of conserved global regulators and small molecules like c-di-GMP and (p)ppGpp, which play key roles in cell cycle control. It also describes several newly identified mechanisms that modulate cell cycle progression in response to stresses or environmental conditions.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Alphaproteobacteria / cytology*
  • Alphaproteobacteria / genetics
  • Alphaproteobacteria / metabolism
  • Bacterial Proteins / genetics
  • Bacterial Proteins / metabolism
  • Cell Cycle*
  • Cyclic GMP / analogs & derivatives
  • Cyclic GMP / metabolism
  • Gene Expression Regulation, Bacterial


  • Bacterial Proteins
  • bis(3',5')-cyclic diguanylic acid
  • Cyclic GMP