A Mechanism for Somatic Brain Mosaicism

Cell. 2016 Feb 11;164(4):593-5. doi: 10.1016/j.cell.2016.01.048.


Double-strand break repair is required for neural development, and brain cells contain somatic genomic variations. Now, Wei et al. demonstrate that neural stem and progenitor cells undergo very frequent DNA breaks in a very restricted set of genes involved in neural cell adhesion and synapse function.

Publication types

  • Comment

MeSH terms

  • Animals
  • DNA Breaks*
  • Humans
  • Neural Stem Cells / metabolism*