Acute intermittent porphyria precipitated by atazanavir/ritonavir

Int J STD AIDS. 2016 Nov;27(13):1234-1235. doi: 10.1177/0956462416633981. Epub 2016 Feb 11.


Porphyrias are a group of metabolic disorders that are relatively uncommon and underdiagnosed. Although the association between HIV infection and antiretrovirals with porphyria cutanea tarda is well established, there are fewer data linking HIV and the acute hepatic porphyrias. We report the first case of acute intermittent porphyria precipitated by the drugs atazanavir and ritonavir, presenting with unexplained abdominal pain.

Keywords: AIDS; HIV; acute porphyria; antiretrovirals and porphyria; atazanavir and porphyria; porphyria; protease inhibitors; ritonavir and porphyria.

Publication types

  • Case Reports

MeSH terms

  • Abdominal Pain / etiology
  • Atazanavir Sulfate / adverse effects*
  • Atazanavir Sulfate / therapeutic use
  • Female
  • HIV Infections / drug therapy*
  • Humans
  • Middle Aged
  • Porphyria, Acute Intermittent / chemically induced*
  • Porphyria, Acute Intermittent / diagnosis
  • Protease Inhibitors / adverse effects*
  • Protease Inhibitors / therapeutic use
  • Ritonavir / adverse effects*
  • Ritonavir / therapeutic use
  • Treatment Outcome


  • Protease Inhibitors
  • Atazanavir Sulfate
  • Ritonavir