Effectiveness of Anise Oil for Treatment of Mild to Moderate Depression in Patients With Irritable Bowel Syndrome: A Randomized Active and Placebo-Controlled Clinical Trial

J Evid Based Complementary Altern Med. 2017 Jan;22(1):41-46. doi: 10.1177/2156587216628374. Epub 2016 Feb 11.


Depression is a prevalent disorder among patients suffering from irritable bowel syndrome. The current study was performed to evaluate the effect of a traditional Persian medicine product, anise oil, in removing the symptoms of mild to moderate depression in patients with irritable bowel syndrome. In a randomized double-blinded active and placebo controlled clinical trial, 120 participants with mild to moderate depression according to the Beck Depression Inventory-II total scores were categorized into 3 equal groups and received anise oil, Colpermin, and placebo. The results at the end of trial (week 4) and follow-up (week 6) demonstrated significant priority against active and placebo groups. Although the mechanism is unknown yet, anise oil could be a promising choice of treatment for depressed patients with irritable bowel syndrome.

Keywords: anise; depression; irritable bowel syndrome; traditional Persian medicine.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Depression / drug therapy*
  • Depression / etiology*
  • Female
  • Humans
  • Irritable Bowel Syndrome / complications*
  • Male
  • Medicine, Arabic
  • Middle Aged
  • Oils, Volatile / therapeutic use*
  • Pimpinella*
  • Plant Oils / therapeutic use*
  • Young Adult


  • Oils, Volatile
  • Plant Oils