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. 2016 Apr 1;455:149-53.
doi: 10.1016/j.cca.2016.02.007. Epub 2016 Feb 10.

Postoperative Plasma 8-iso-prostaglandin F2α Levels Are Associated With Delirium and Cognitive Dysfunction in Elderly Patients After Hip Fracture Surgery

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Postoperative Plasma 8-iso-prostaglandin F2α Levels Are Associated With Delirium and Cognitive Dysfunction in Elderly Patients After Hip Fracture Surgery

Yuan-Bo Zheng et al. Clin Chim Acta. .

Abstract

Background: Oxidative stress may be involved in occurrence of postoperative delirium (POD) and cognitive dysfunction (POCD). 8-iso-Prostaglandin F2α (8-iso-PGF2α), an isoprostane derived from arachidonic acid via lipid peroxidation, is considered a gold standard for measuring oxidative stress. The present study aimed to investigate the ability of postoperative plasma 8-iso-PGF2α levels to predict POD and POCD in elderly patients undergoing hip fracture surgery.

Methods: Postoperative plasma 8-iso-PGF2α levels of 182 patients were measured by an enzyme-linked immunosorbent assay. We assessed the relationships between plasma 8-iso-PGF2α levels and the risk of POD and POCD using a multivariate analysis.

Results: Plasma 8-iso-PGF2α levels and age were identified as the independent predictors for POD and POCD. Based on areas under receiver operating characteristic curve, the predictive values of 8-iso-PGF2α were obviously higher than those of age for POD and POCD. In a combined logistic-regression model, 8-iso-PGF2α significantly enhanced the areas under curve of age for prediction of POD and POCD.

Conclusions: Postoperative plasma 8-iso-PGF2α levels may have the potential to predict POD and POCD in elder patients undergoing hip fracture surgery.

Keywords: 8-iso-Prostaglandin F2α; Cognitive dysfunction; Delirium; Elderly; Hip fracture; Postoperative.

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