Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 17 (3), 146-59

Cheating Evolution: Engineering Gene Drives to Manipulate the Fate of Wild Populations

Affiliations
Review

Cheating Evolution: Engineering Gene Drives to Manipulate the Fate of Wild Populations

Jackson Champer et al. Nat Rev Genet.

Abstract

Engineered gene drives - the process of stimulating the biased inheritance of specific genes - have the potential to enable the spread of desirable genes throughout wild populations or to suppress harmful species, and may be particularly useful for the control of vector-borne diseases such as malaria. Although several types of selfish genetic elements exist in nature, few have been successfully engineered in the laboratory thus far. With the discovery of RNA-guided CRISPR-Cas9 (clustered regularly interspaced short palindromic repeats-CRISPR-associated 9) nucleases, which can be utilized to create, streamline and improve synthetic gene drives, this is rapidly changing. Here, we discuss the different types of engineered gene drives and their potential applications, as well as current policies regarding the safety and regulation of gene drives for the manipulation of wild populations.

Comment in

Similar articles

See all similar articles

Cited by 67 PubMed Central articles

See all "Cited by" articles

References

    1. Cold Spring Harb Perspect Biol. 2014 Dec 18;7(2):a017616 - PubMed
    1. Annu Rev Entomol. 2013;58:413-32 - PubMed
    1. Nature. 2011 Aug 24;476(7361):454-7 - PubMed
    1. Cell Res. 2013 May;23(5):720-3 - PubMed
    1. Science. 2014 Aug 29;345(6200):1010-1 - PubMed

Publication types

LinkOut - more resources

Feedback