A randomized, double-blind, placebo controlled, parallel group, efficacy study of alpha BRAIN® administered orally

Hum Psychopharmacol. 2016 Mar;31(2):135-43. doi: 10.1002/hup.2520. Epub 2016 Feb 15.


Objective: Alpha BRAIN® is a nootropic supplement that purports to enhance cognitive functioning in healthy adults. The goal of this study was to investigate the efficacy of this self-described cognitive enhancing nootropic on cognitive functioning in a group of healthy adults by utilizing a randomized, double blind, placebo-controlled design.

Methods: A total of 63-treatment naïve individuals between 18 and 35 years of age completed the randomized, double-blind, placebo controlled trial. All participants completed a 2-week placebo run in before receiving active product, Alpha BRAIN® or new placebo, for 6 weeks. Participants undertook a battery of neuropsychological tests at randomization and at study completion. Primary outcome measures included a battery of neuropsychological tests and measures of sleep.

Results: Compared with placebo, Alpha BRAIN® significantly improved on tasks of delayed verbal recall and executive functioning. Results also indicated significant time-by-group interaction in delayed verbal recall for the Alpha BRAIN® group.

Conclusions: The use of Alpha BRAIN® for 6 weeks significantly improved recent verbal memory when compared with controls, in a group of healthy adults. While the outcome of the study is encouraging, this is the first randomized controlled trial of Alpha BRAIN®, and the results merit further study.

Keywords: cognitive enhancement; nootropic; nutraceutical; randomized controlled trial.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Oral
  • Adolescent
  • Adult
  • Dietary Supplements*
  • Double-Blind Method
  • Executive Function
  • Humans
  • Mental Recall
  • Neuropsychological Tests
  • Nootropic Agents / administration & dosage*
  • Pharmaceutical Preparations / administration & dosage*
  • Sleep
  • Speech Perception
  • Treatment Outcome
  • Young Adult


  • Nootropic Agents
  • Pharmaceutical Preparations
  • alpha BRAIN