Nutrition and Bipolar Depression

Psychiatr Clin North Am. 2016 Mar;39(1):75-86. doi: 10.1016/j.psc.2015.10.003. Epub 2015 Dec 23.


As with physical conditions, bipolar disorder is likely to be impacted by diet and nutrition. Patients with bipolar disorder have been noted to have relatively unhealthy diets, which may in part be the reason they also have an elevated risk of metabolic syndrome and obesity. An improvement in the quality of the diet should improve a bipolar patient's overall health risk profile, but it may also improve their psychiatric outcomes. New insights into biological dysfunctions that may be present in bipolar disorder have presented new theoretic frameworks for understanding the relationship between diet and bipolar disorder.

Keywords: Bipolar depression; Diet; Mediterranean diet; N-acetylcysteine; Nutrition; Omega-3 fatty acids; Vitamin D.

Publication types

  • Review

MeSH terms

  • Bipolar Disorder / diet therapy*
  • Diet / adverse effects*
  • Diet, Mediterranean*
  • Fatty Acids, Omega-3
  • Humans
  • Nutritional Status*


  • Fatty Acids, Omega-3