Mean Platelet Volume, a Novel Biomarker in Adolescents with Severe Primary Dysmenorrhea

J Pediatr Adolesc Gynecol. 2016 Aug;29(4):390-2. doi: 10.1016/j.jpag.2016.01.128. Epub 2016 Feb 11.


Study objective: To evaluate whether mean platelet volume (MPV) would be a profitable marker in predicting disease severity in adolescents with severe primary dysmenorrhea (PD). DESIGN, SETTING, PARTICIPANTS, INTERVENTIONS, AND MAIN OUTCOME MEASURES: A total of 67 patients diagnosed with PD and 37 healthy adolescents with regular menstrual cycles were included in the study. Hemoglobin, MPV, and white blood cell, platelet, lymphocyte, and neutrophil counts were measured as part of the automated complete blood examination. Neutrophil to lymphocyte ratio and platelet to lymphocyte ratio were obtained from the absolute neutrophil or platelet count, respectively, divided by the absolute lymphocyte count. The visual analog scale was used to assess the level of pain, as mild (<40 mm), moderate (40-60 mm) and severe (>60 mm) PD.

Results: The MPV level of the combined severity of PD and control groups were similar. However, the MPV was significantly lower in the severe PD group compared with the control group (P = .04). There were no significant differences in the other hematological parameters between the groups. The mean visual analog scale score of the PD and control subjects were 7.35 ± 2.25 and 1.07 ± 1.96, respectively (P < .01). There was a poor negative correlation, which was statistically insignificant, between MPV and white blood cell count.

Conclusion: The present study showed that MPV is decreased in adolescents with severe PD. Further studies with larger numbers of subjects are necessary to clarify the roles of platelets in the pathogenesis of severe PD and evaluate the changes in MPV value in response to treatment.

Keywords: Adolescent; Mean platelet volume; Pelvic pain; Platelet; Primary dysmenorrhea; Visual analog scale.

MeSH terms

  • Adolescent
  • Biomarkers / blood
  • Case-Control Studies
  • Cross-Sectional Studies
  • Dysmenorrhea / blood*
  • Female
  • Humans
  • Leukocyte Count
  • Mean Platelet Volume*
  • Menstrual Cycle / blood*
  • Neutrophils*
  • Platelet Count*
  • Prospective Studies
  • Risk Factors
  • Young Adult


  • Biomarkers