Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2016 Aug;62(3):533-45.
doi: 10.1007/s00294-016-0578-2. Epub 2016 Feb 15.

Regulation of the Fungal Secretome

Affiliations
Review

Regulation of the Fungal Secretome

Sean W McCotter et al. Curr Genet. .

Abstract

The ability of countless representatives of the Kingdom Fungi to adapt to and proliferate in diverse environments is facilitated by regulation of their secretomes to respond to changes in environmental conditions and to mediate interactions with other organisms. Secretome changes often fulfill common functions of nutrient acquisition, facilitation of host/symbiont interactions, cell wall modification, and optimization of the enzyme suite to adapt to new environmental resources. In this review, we expand on our recent work on signaling and the secretome in the pathogenic fungus Cryptococcus neoformans to consider a range of selected examples of regulation of fungal secretomes. These examples include the impact of carbon source and aspects of the response to plant and animal hosts. Additionally, the influence of key protein kinases (e.g., Pka1, Snf1) and transcription factors (e.g., Rim101/PacC) is highlighted to illustrate some underlying regulatory factors influencing the secretome. Although there is a wealth of information about fungal secretomes from both experimentation and genome sequence mining, there are also major gaps in our knowledge about the complete composition of fungal secretomes and mechanisms of dynamic change. For example, a more comprehensive understanding of the composition and regulation of the secretome will require consideration of the emerging roles of unconventional secretion and extracellular vesicles in delivering proteins outside the cell. Overall, changes in the secretome are well documented in diverse fungi and the underlying mechanisms are currently under investigation; however, there remain unknown steps in the regulation of secretory pathways and gaps in understanding the regulation of unconventional secretion, which warrant further research.

Keywords: Biomass degradation; Effectors; Fungal pathogenesis; Nutrient regulation; Secretion; Signal transduction.

Similar articles

See all similar articles

Cited by 18 articles

See all "Cited by" articles

References

    1. J Proteome Res. 2011 Jul 1;10(7):3136-48 - PubMed
    1. Microbiology. 2002 Nov;148(Pt 11):3743-54 - PubMed
    1. Med Mycol. 2006 Nov;44(7):641-5 - PubMed
    1. Proteome Sci. 2012 Jun 12;10(1):40 - PubMed
    1. Curr Opin Genet Dev. 2015 Dec;35:57-65 - PubMed

LinkOut - more resources

Feedback