Schizophrenia as a prodromal symptom in a patient harboring SNCA duplication

Shogo Takamura; Aya Ikeda; Kenya Nishioka; Hirokazu Furuya; Mari Tashiro; Takashi Matsushima; Yuanzhe Li; Hiroyo Yoshino; Manabu Funayama; Shigeru Morinobu; Nobutaka Hattori

doi:10.1016/j.parkreldis.2016.01.028

Schizophrenia as a prodromal symptom in a patient harboring SNCA duplication

Parkinsonism Relat Disord. 2016 Apr:25:108-9. doi: 10.1016/j.parkreldis.2016.01.028. Epub 2016 Feb 8.

Authors

Affiliations

¹ Department of Neuropsychiatry, Kochi Medical School Hospital, Kochi Medical School, Kohasu, Oko-cho, Nankoku, Kochi-ken 783-8505, Japan.
² Department of Neurology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.
³ Department of Neurology, Kochi Medical School Hospital, Kochi Medical School, Kohasu, Oko-cho, Nankoku, Kochi-ken 783-8505, Japan.
⁴ Department of Clinical Genetics, Kochi Medical School Hospital, Kochi Medical School, Kohasu, Oko-cho, Nankoku, Kochi-ken 783-8505, Japan.
⁵ Research Institute for Diseases of Old Age, Graduate School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.
⁶ Department of Neurology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan; Research Institute for Diseases of Old Age, Graduate School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.
⁷ Department of Neurology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan; Research Institute for Diseases of Old Age, Graduate School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan. Electronic address: nhattori@juntendo.ac.jp.

PMID: 26880146
DOI: 10.1016/j.parkreldis.2016.01.028

Abstract

We present the case of a patient who developed delusions and auditory hallucinations and was clinically diagnosed as having schizophrenia. Ten years after the onset of schizophrenia, the disease progressed to mild parkinsonism. SNCA duplication was confirmed. This case expands the spectrum of clinical features in carriers of SNCA duplication.

Keywords: Dementia with Lewy bodies; Parkinson's disease; Psychosis; SNCA duplication; Schizophrenia.

Publication types

Case Reports
Letter
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Humans
Male
Parkinson Disease / genetics*
Parkinson Disease / psychology
Pedigree
Prodromal Symptoms*
Schizophrenia / genetics*
alpha-Synuclein / genetics*

Substances

SNCA protein, human
alpha-Synuclein