The translational relevance of Drosophila in drug discovery

Ismael Fernández-Hernández; Eulalia Scheenaard; Giulia Pollarolo; Cayetano Gonzalez

doi:10.15252/embr.201642080

The translational relevance of Drosophila in drug discovery

EMBO Rep. 2016 Apr;17(4):471-2. doi: 10.15252/embr.201642080. Epub 2016 Feb 16.

Authors

Ismael Fernández-Hernández¹, Eulalia Scheenaard¹, Giulia Pollarolo¹, Cayetano Gonzalez²

Affiliations

¹ Cell Division Group, Institute for Research in Biomedicine (IRB Barcelona) The Barcelona Institute of Science and Technology, Barcelona, Spain.
² Cell Division Group, Institute for Research in Biomedicine (IRB Barcelona) The Barcelona Institute of Science and Technology, Barcelona, Spain Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain.

Abstract

Drosophila might be a suitable tool for drug discovery, but it is not clear how often the compounds identified will work in humans. A detailed look at previous work suggests that compounds active in both species might be relatively common.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Drosophila Proteins / chemistry
Drosophila Proteins / genetics
Drosophila Proteins / metabolism
Drosophila* / genetics
Drosophila* / physiology
Drug Discovery*
Humans
Models, Animal*
Proteomics
Translational Research, Biomedical*

Substances

Drosophila Proteins