Two New Oxindole Alkaloid Glycosides from the Leaves of Nauclea officinalis

Nat Prod Commun. 2015 Dec;10(12):2087-90.

Abstract

Two new oxindole alkaloid glycosides, nauclealomide A and (3S,7R)-javaniside, were isolated from the leaves of Nauclea officinalis. Their structures and absolute configurations were elucidated by means of NMR, HRESIMS, X-ray diffraction, acid hydrolysis and quantum chemical CD calculation. Nauclealomide A is a novel monoterpenoid oxindole alkaloid possessing a rare tetrahydro-2H-1,3-oxazine ring.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkaloids / chemistry*
  • Glycosides / chemistry*
  • Models, Molecular
  • Plant Leaves / chemistry*
  • Rubiaceae / chemistry*

Substances

  • Alkaloids
  • Glycosides
  • nauclealomide A