Effect of rosuvastatin dose-loading on serum sLox-1, hs-CRP, and postoperative prognosis in diabetic patients with acute coronary syndromes undergoing selected percutaneous coronary intervention (PCI)

Yungen Jiao; Feng Hu; Zhengang Zhang; Kaizheng Gong; Xiaoning Sun; Aihua Li; Naifeng Liu

Effect of rosuvastatin dose-loading on serum sLox-1, hs-CRP, and postoperative prognosis in diabetic patients with acute coronary syndromes undergoing selected percutaneous coronary intervention (PCI)

Int J Clin Exp Med. 2015 Nov 15;8(11):21565-71. eCollection 2015.

Authors

Yungen Jiao¹, Feng Hu², Zhengang Zhang², Kaizheng Gong², Xiaoning Sun², Aihua Li², Naifeng Liu³

Affiliations

¹ Institute of Cardiovascular for Southeast University, Department of Cardiology, Zhongda Hospital of Southeast University Medical SchoolNanjing 210000, China; Department of Cardiology, First People's Hospital of Yangzhou, The Second Clinical Medical School of Yangzhou UniversityYangzhou 225400, China.
² Department of Cardiology, First People's Hospital of Yangzhou, The Second Clinical Medical School of Yangzhou University Yangzhou 225400, China.
³ Institute of Cardiovascular for Southeast University, Department of Cardiology, Zhongda Hospital of Southeast University Medical School Nanjing 210000, China.

PMID: 26885106
PMCID: PMC4723951

Abstract

Objective: To investigate the effect of rosuvastatin dose-loading on serum levels of lectin-like oxidized low-density lipoprotein receptor-1 (Lox-1) and high-sensitivity c-reactive protein (hs-CRP) and postoperative prognosis in patients with diabetes and non-ST segment elevation acute coronary syndromes (NSTEACS) undergoing selected percutaneous coronary intervention (PCI).

Methods: A total of 72 patients with diabetes and NSTEACS were randomized to either the group treated with 20 mg rosuvastatin 12 hours prior to PCI with a second dose administered just before PCI (n = 33), or a control group treated with standard method according guideline (n = 39). Serum levels of sLox-1, hs-CRP, CK-MB, and cTnI were measured prior to PCI, and at 24 hours and 30 days after PCI. The 30-day incidence of major adverse cardiac events (MACE) was recorded in both groups.

Results: Compared to pre-PCI, serum levels of sLox-1 and hs-CRP of the two groups were increased at 24 hours after PCI (P < 0.05); the levels of CK-MB and cTnI were also improved (P < 0.01); however, the ascended values of sLox-1, hs-CRP, CK-MB, and cTnI were significantly lower in the loading-dose rosuvastatin-treated group than in the control-treated group. Serum levels of sLox-1 and hs-CRP were higher in the loading-dose rosuvastatin-treated group than in the control-treated group at 30 days after PCI (P < 0.05); compared to pre-PCI, the levels of TC and LDL-C were not changed at 24 hours after PCI (P > 0.05) until 30 days after PCI (P < 0.05), but there were no difference between the two groups. The levels of ALT and Scr had no significant difference between the two groups before and after PCI; the 30-day incidence of MACE occurred in 6.06% of patients in the loading-dose rosuvastatin-treated group and in 23.08% of patients in the control-treated group (P < 0.05).

Conclusion: The therapy of dose-loading rosuvastatin for patients with diabetes and non-ST segment elevation acute coronary syndromes undergoing selected percutaneous coronary intervention can attenuate the increase of serum levels of sLox-1, reduce myocardial injury and inflammatory reaction caused by PCI, and also reduce the occurrence of MACE 30 days after PCI.

Keywords: Lectin-like oxidized low density lipoprotein receptor-1; acute coronary syndrome; percutaneous coronary intervention; rosuvastatin.