Vitamin D Deficiency Is Not Associated With Diabetic Retinopathy or Maculopathy

J Diabetes Res. 2016;2016:6156217. doi: 10.1155/2016/6156217. Epub 2016 Jan 14.

Abstract

Background: Experimental and clinical studies suggest a possible association between vitamin D deficiency and both diabetic retinopathy and maculopathy.

Methods: We have performed a cross-sectional study in adults with types 1 and 2 diabetes mellitus. The relationship between the presence and severity of diabetic retinopathy and maculopathy with serum 25-hydroxyvitamin D concentration was evaluated using logistic regression analyses in the presence of demographic and clinical covariates.

Results: 657 adults with diabetes were stratified based on retinopathy grading: No Diabetic Retinopathy (39%), Background Diabetic Retinopathy (37%), Preproliferative Diabetic Retinopathy (21%), and Proliferative Diabetic Retinopathy (3%), respectively. There were no differences in serum 25-hydroxyvitamin D concentrations (25(OH)D) between the groups (15.3 ± 9.0 versus 16.4 ± 10.5 versus 15.9 ± 10.4 versus 15.7 ± 8.5 ng/mL, P = NS). Logistic regression analysis demonstrated no statistically significant relationship between the severity of retinopathy and serum 25(OH)D. Furthermore, there was no difference in serum 25(OH)D between those with (n = 94, 14%) and those without (n = 563, 86%) Diabetic Maculopathy (16.2 ± 10.0 versus 15.8 ± 9.8, P = NS) and no relationship was demonstrated by logistic regression analyses between the two variables.

Conclusions: This study has found no association between serum 25(OH)D and the presence and severity of diabetic retinopathy or maculopathy.

MeSH terms

  • Adult
  • Aged
  • Anthropometry
  • Blood Pressure
  • Cross-Sectional Studies
  • Diabetes Mellitus, Type 1 / blood
  • Diabetes Mellitus, Type 2 / blood
  • Diabetic Retinopathy / complications*
  • Diabetic Retinopathy / diagnosis
  • Female
  • Humans
  • Macular Degeneration / complications*
  • Macular Degeneration / diagnosis
  • Male
  • Middle Aged
  • Regression Analysis
  • Vitamin D / analogs & derivatives
  • Vitamin D / blood
  • Vitamin D Deficiency / complications*
  • Vitamin D Deficiency / diagnosis

Substances

  • Vitamin D
  • 25-hydroxyvitamin D