Costimulation Engages the Gear in Driving CARs

Immunity. 2016 Feb 16;44(2):214-6. doi: 10.1016/j.immuni.2016.02.001.

Abstract

In this issue of Immunity,Kawalekar et al. (2016) find that costimulation by a chimeric antigen receptor (CAR) can control T cell metabolism and balance the response toward long-lived memory or short-lived effector cells. The results provide a rationale of how to tune cancer immunotherapy more effectively in a hostile tumor environment.

Publication types

  • Comment

MeSH terms

  • CD28 Antigens / metabolism*
  • CD8-Positive T-Lymphocytes / physiology*
  • Cancer Vaccines / immunology*
  • Humans
  • Immunotherapy*
  • Neoplasms / therapy*
  • Receptors, Antigen, T-Cell / metabolism*
  • Tumor Necrosis Factor Receptor Superfamily, Member 9 / metabolism*

Substances

  • CD28 Antigens
  • Cancer Vaccines
  • Receptors, Antigen, T-Cell
  • Tumor Necrosis Factor Receptor Superfamily, Member 9