Increased Oxidative Stress in Children With Attention Deficit Hyperactivity Disorder

Redox Rep. 2016 Nov;21(6):248-53. doi: 10.1080/13510002.2015.1116729. Epub 2016 Feb 18.

Abstract

Objectives: The purpose of this study was to investigate oxidative stress in children with attention deficit hyperactivity disorder (ADHD).

Methods: Total oxidant status (TOS), total antioxidant status (TAS), paraxonase-1 (PON-1) and arylesterase (ARE) activity were measured in 76 children (44 boys, 32 girls) diagnosed with ADHD according to the DSM-IV and 78 healthy children (46 boys, 32 girls).

Results: Age and sex were similar between the groups (P > 0.05). TOS and the oxidative stress index (OSI) were higher in the patient group than the control group (P < 0.001). PON-1 (P = 0.002), ARE (P = 0.010) activity and TAS (P < 0.001) were lower in the patient group than the control group.

Discussion: We found decreased PON-1, ARE activity and TAS, and increased TOS and OSI in children with ADHD. Our study showed that there is significantly increased oxidative stress in children with ADHD.

Keywords: Arylesterase; Attention deficit hyperactivity disorder; Oxidative stress; Paraxonase-1.

MeSH terms

  • Adolescent
  • Antioxidants / metabolism
  • Aryldialkylphosphatase / metabolism
  • Attention Deficit Disorder with Hyperactivity / metabolism*
  • Attention Deficit Disorder with Hyperactivity / physiopathology*
  • Carboxylic Ester Hydrolases / metabolism
  • Child
  • Female
  • Humans
  • Male
  • Oxidation-Reduction
  • Oxidative Stress / physiology*

Substances

  • Antioxidants
  • Carboxylic Ester Hydrolases
  • arylesterase
  • Aryldialkylphosphatase
  • PON1 protein, human