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. 2016 Feb 17;11(2):e0148435.
doi: 10.1371/journal.pone.0148435. eCollection 2016.

Is Toxoplasma Gondii Infection Related to Brain and Behavior Impairments in Humans? Evidence from a Population-Representative Birth Cohort

Karen Sugden  1   2 , Terrie E Moffitt  1   2   3   4 , Lauriane Pinto  2 , Richie Poulton  5 , Benjamin S Williams  1   2 , Avshalom Caspi  1   2   3   4
Affiliations

Is Toxoplasma Gondii Infection Related to Brain and Behavior Impairments in Humans? Evidence from a Population-Representative Birth Cohort

Karen Sugden et al. PLoS One. .

Abstract

Background: Toxoplasma gondii (T. gondii) is a protozoan parasite present in around a third of the human population. Infected individuals are commonly asymptomatic, though recent reports have suggested that infection might influence aspects of the host's behavior. In particular, Toxoplasma infection has been linked to schizophrenia, suicide attempt, differences in aspects of personality and poorer neurocognitive performance. However, these studies are often conducted in clinical samples or convenience samples.

Methods/results: In a population-representative birth-cohort of individuals tested for presence of antibodies to T. gondii (N = 837) we investigated the association between infection and four facets of human behavior: neuropsychiatric disorder (schizophrenia and major depression), poor impulse control (suicidal behavior and criminality), personality, and neurocognitive performance. Suicide attempt was marginally more frequent among individuals with T. gondii seropositivity (p = .06). Seropositive individuals also performed worse on one out of 14 measures of neuropsychological function.

Conclusion: On the whole, there was little evidence that T. gondii was related to increased risk of psychiatric disorder, poor impulse control, personality aberrations or neurocognitive impairment.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

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References

    1. Flegr J., Prandota J., Sovickova M., and Israili Z.H., Toxoplasmosis—a global threat. Correlation of latent toxoplasmosis with specific disease burden in a set of 88 countries. PLoS One, 2014; 9(3): p. e90203 10.1371/journal.pone.0090203 - DOI - PMC - PubMed
    1. Furtado J.M., Smith J.R., Belfort R. Jr., Gattey D., and Winthrop K.L., Toxoplasmosis: a global threat. J Glob Infect Dis, 2011; 3(3): p. 281–4. 10.4103/0974-777X.83536 - DOI - PMC - PubMed
    1. Flegr J., Influence of latent Toxoplasma infection on human personality, physiology and morphology: pros and cons of the Toxoplasma-human model in studying the manipulation hypothesis. J Exp Biol, 2013; 216(Pt 1): p. 127–33. 10.1242/jeb.073635 - DOI - PubMed
    1. Ingram W.M., Goodrich L.M., Robey E.A., and Eisen M.B., Mice infected with low-virulence strains of Toxoplasma gondii lose their innate aversion to cat urine, even after extensive parasite clearance. PLoS One, 2013; 8(9): p. e75246 10.1371/journal.pone.0075246 - DOI - PMC - PubMed
    1. Kannan G., Moldovan K., Xiao J.C., Yolken R.H., Jones-Brando L., and Pletnikov M.V., Toxoplasma gondii strain-dependent effects on mouse behaviour. Folia Parasitol (Praha), 2010; 57(2): p. 151–5. - PubMed

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