Efficacy and Tolerability of Lacosamide in the Treatment of Children With Refractory Generalized Epilepsy

J Child Neurol. 2016 Jun;31(7):925-8. doi: 10.1177/0883073816630084. Epub 2016 Feb 16.


Lacosamide is FDA-approved in patients 17 years or older with partial-onset epilepsy. We evaluated the efficacy and tolerability of lacosamide in children with refractory generalized epilepsy. We retrospectively reviewed records of 21 children with refractory generalized epilepsy treated with lacosamide in our institution from 2009-2013 divided into 2 subgroups- I, Lennox-Gastaut Syndrome, and II, other generalized epilepsies. Efficacy was defined as seizure freedom or ≥50% seizure reduction. Descriptive data analysis including seizure freedom was compared using c(2) analysis. There were eleven females and ten males with a mean age, of 11.9 years. Five patients became seizure free, nine had ≥50% seizure reduction, and seven had no response. Group I: seven had ≥50% improvement, one did not respond. Group II: five became seizure free, two had ≥50% improvement, five had no response. Lacosamide is effective and well tolerated in children with refractory generalized epilepsy particularly patients with Lennox-Gastaut Syndrome.

Keywords: Lennox-Gastaut syndrome; children; generalized epilepsy; lacosamide.

MeSH terms

  • Acetamides / adverse effects
  • Acetamides / therapeutic use*
  • Adolescent
  • Anticonvulsants / adverse effects
  • Anticonvulsants / therapeutic use*
  • Child
  • Child, Preschool
  • Drug Resistant Epilepsy / drug therapy*
  • Drug Resistant Epilepsy / physiopathology
  • Epilepsy, Generalized / drug therapy*
  • Epilepsy, Generalized / physiopathology
  • Female
  • Humans
  • Lacosamide
  • Male
  • Retrospective Studies
  • Seizures / drug therapy
  • Seizures / physiopathology
  • Treatment Outcome
  • Young Adult


  • Acetamides
  • Anticonvulsants
  • Lacosamide