The current role of Gamma Knife radiosurgery in the management of intracranial haemangiopericytoma

Acta Neurochir (Wien). 2016 Apr;158(4):635-642. doi: 10.1007/s00701-016-2742-3. Epub 2016 Feb 18.


Background: Haemangiopericytomas (HPCs) are rare tumours characterised by aggressive behaviour with tendency to local recurrence and to metastasise. WHO grade II and grade III tumours show different progression-free survival and overall survival rates. Gross total tumour resection is still considered the treatment of choice. Adjuvant radiation therapies represent an option in the treatment strategy regardless the extent of resection. Based on this consideration, Gamma Knife radiosurgery has been introduced either as a primary treatment or as an adjuvant treatment for residual or recurrent tumours.

Method: A systematic search was performed on PubMed, Web of Science and Google Scholar for clinical series reporting Gamma Knife radiosurgery, Cyberknife and Linear Accelerator (LINAC) for the management of intracranial HPCs.

Results: Fourteen studies focusing on the effects of Gamma Knife radiosurgery for intracranial HPCs were included. Four studies reported data on Cyberknife radiosurgery and LINAC. A total of 208 patients harbouring 366 tumours have been reported. Patient's features, radiosurgical treatment characteristics and follow-up data of the pertinent literature have been critically revised.

Conclusions: Gamma Knife radiosurgery and the other radiosurgical techniques represent a feasible and effective therapy in the management of HPCs. Tumour control and survival rate are comparable to those reported for radiotherapy. Further studies should be focused to define the exact role of Gamma Knife radiosurgery in the management of HPCs.

Keywords: Brain tumour; Gamma Knife, radiosurgery; Haemangiopericytoma; Radiation therapy; Surgery.

Publication types

  • Meta-Analysis
  • Review

MeSH terms

  • Adult
  • Aged
  • Brain Neoplasms / radiotherapy*
  • Female
  • Hemangiopericytoma / radiotherapy*
  • Humans
  • Male
  • Middle Aged
  • Radiosurgery / adverse effects*
  • Radiosurgery / methods
  • Survival Analysis