Monoclonal antibody therapy in multiple myeloma: where do we stand and where are we going?

Immunotherapy. 2016;8(3):367-84. doi: 10.2217/imt.15.118. Epub 2016 Feb 17.


Multiple myeloma is a plasma cell malignancy that is characterized by refractory and relapsing course of disease. Despite the introduction of high-dose chemotherapy in combination with autologous stem cell transplantation and innovative agents such as proteasome inhibitors and immunomodulatory drugs, achieving cure in multiple myeloma is a challenging endeavor. In the last couple of years, enormous advances were made in implementing monoclonal antibody therapy in multiple myeloma. A large number of preclinical and clinical studies have been introduced successfully, demonstrating a safe and efficient administration of monoclonal antibodies in multiple myeloma. In particular, the application of monoclonal antibodies in combination with immunomodulatory drugs, proteasome inhibitors, corticosteroids or conventional chemotherapy seem to be promising and will expand the treatment arsenal for patients with multiple myeloma.

Keywords: immunotherapy; monoclonal antibodies; multiple myeloma; targeted therapy.

Publication types

  • Review

MeSH terms

  • Animals
  • Antibodies, Monoclonal / therapeutic use*
  • Clinical Trials as Topic
  • Combined Modality Therapy
  • Disease Models, Animal
  • Humans
  • Immunologic Factors / therapeutic use*
  • Immunotherapy / methods*
  • Immunotherapy / trends
  • Multiple Myeloma / immunology
  • Multiple Myeloma / therapy*
  • Proteasome Inhibitors / therapeutic use*


  • Antibodies, Monoclonal
  • Immunologic Factors
  • Proteasome Inhibitors