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Randomized Controlled Trial
, 20 (9), 2575-2580

Oral Manifestations of Rheumatoid Arthritis. A Cross-Sectional Study of 73 Patients

Randomized Controlled Trial

Oral Manifestations of Rheumatoid Arthritis. A Cross-Sectional Study of 73 Patients

Javier Silvestre-Rangil et al. Clin Oral Investig.


Objective: A study is made of the main oral manifestations of patients with rheumatoid arthritis (RA), particularly salivary flow, and of its possible association to periodontal disease.

Material and methods: A prospective comparative study was made of 146 patients (73 with RA and 73 controls), recording pocket depth, clinical attachment loss, bleeding index, plaque index, and the DMFT index to assess periodontal and dental alterations. Sialometric measurements were also made to determine resting, stimulated, and parotid salivary flow.

Results: The patients with RA had greater periodontal pocket depths (with moderate depths in most cases), as well as greater attachment loss and more bacterial plaque. The resting whole saliva and stimulated parotid saliva rates were also clearly decreased in the RA group compared with the controls.

Conclusions: Patients with RA are more likely to present periodontal disease, poorer oral hygiene manifesting as an increased accumulation of bacterial plaque, and decreased salivary flow rates.

Clinical relevance: Vulnerability to periodontitis is confirmed in one of the largest samples ever studied of patients with rheumatoid arthritis (RA). Also, there is evidence of hyposialia (decrease in salivary rate) in RA patients without Sjögren's syndrome.

Keywords: Dental caries; Oral manifestations; Periodontal disease; Rheumatoid arthritis; Salivary flow.

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    1. Ann Rheum Dis. 1985 Jan;44(1):20-6 - PubMed
    1. Community Dent Oral Epidemiol. 1989 Oct;17(5):234-6 - PubMed
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    1. Rheumatology (Oxford). 2003 Oct;42(10):1234-41 - PubMed
    1. J Periodontol. 2007 Dec;78(12):2311-8 - PubMed

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