A randomized, double blind, placebo controlled study of spirulina supplementation on indices of mental and physical fatigue in men

Int J Food Sci Nutr. 2016;67(2):203-6. doi: 10.3109/09637486.2016.1144719. Epub 2016 Feb 17.


Spirulina may increase people's ability to resist mental and physical fatigue. This study tested that hypothesis in a randomized, double blinded, placebo controlled study in men. After 1 week, a 3 g/day dose of spirulina produced a small, but statistically significant increase in exercise output (Kcals consumed in 30 min exercise on a cross trainer machine). A mathematical based mental fatigue test showed improved performance 4 h after the first time of supplementation as well as 8 weeks later. Similarly, a subjective survey for a sense of physical and mental fatigue showed improvement within 4 h of the first supplementation as well as 8 weeks later. These results show that spirulina intake can affect fatigue in men.

Keywords: Exercise; Uchida–Kraepelin test; mental stress; microalgae.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Dietary Supplements*
  • Double-Blind Method
  • Exercise
  • Fatigue / drug therapy*
  • Humans
  • Male
  • Mental Fatigue / drug therapy*
  • Spirulina*