Ia-positive dendritic cells form a tightly meshed network within the human airway epithelium

Clin Exp Allergy. 1989 Nov;19(6):597-601. doi: 10.1111/j.1365-2222.1989.tb02752.x.


In this report we have employed an alternative tissue-sectioning procedure which provides a plan view of intra-epithelial cell populations within the airway wall. Immunoperoxidase staining of such sections for class II MHC (Ia) antigen revealed the presence of a highly developed intra-epithelial network of Ia-positive dendritic cells, which was not evident employing conventional cross- or longitudinal tissue sections. This finding has important implications for the study of mechanisms underlying allergic and infectious diseases of the respiratory tract.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Dendritic Cells / cytology
  • Dendritic Cells / immunology*
  • Epithelial Cells
  • Epithelium / immunology
  • Histocompatibility Antigens Class II*
  • Humans
  • Immunoenzyme Techniques
  • Microtomy / methods
  • Middle Aged
  • Respiratory System / cytology
  • Respiratory System / immunology*


  • Histocompatibility Antigens Class II