Endothelin is a potent constrictor of the lamb ductus arteriosus

Can J Physiol Pharmacol. 1989 Aug;67(8):902-4. doi: 10.1139/y89-141.


Endothelin was tested on isolated ductus arteriosus preparations from mature fetal lambs. At low PO2 (18-24 Torr; 1 Torr = 133.3 Pa), the compound constricted the vessel dose-dependently over the range from about 10(-10) to 10(-7) M. The contraction was sustained and did not subside even after an extended period of washing. Endothelin was also effective on tissues (PO2,217-231 Torr; indomethacin, 2.8 X 10(-6) M) that had been completely relaxed with CO (CO/O2 ratio, 0.28). CO treatment interferes with a cytochrome P-450 mechanism, which is considered crucial for the contractile response of the vessel to oxygen. These findings are consistent with a role of endothelin in the closure of the ductus arteriosus at birth.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Ductus Arteriosus / drug effects
  • Ductus Arteriosus / embryology
  • Ductus Arteriosus / physiology
  • Embryonic and Fetal Development
  • Endothelins
  • Oxygen / physiology
  • Partial Pressure
  • Peptides / pharmacology*
  • Sheep
  • Vasoconstriction / drug effects
  • Vasoconstrictor Agents / pharmacology


  • Endothelins
  • Peptides
  • Vasoconstrictor Agents
  • Oxygen