Disrupted Intrinsic Connectivity among Default, Dorsal Attention, and Frontoparietal Control Networks in Individuals with Chronic Traumatic Brain Injury

J Int Neuropsychol Soc. 2016 Feb;22(2):263-79. doi: 10.1017/S1355617715001393.

Abstract

Objectives: Individuals with chronic traumatic brain injury (TBI) often show detrimental deficits in higher order cognitive functions requiring coordination of multiple brain networks. Although assessing TBI-related deficits in higher order cognition in the context of network dysfunction is promising, few studies have systematically investigated altered interactions among multiple networks in chronic TBI.

Method: We characterized disrupted resting-state functional connectivity of the default mode network (DMN), dorsal attention network (DAN), and frontoparietal control network (FPCN) whose interactions are required for internally and externally focused goal-directed cognition in chronic TBI. Specifically, we compared the network interactions of 40 chronic TBI individuals (8 years post-injury on average) with those of 17 healthy individuals matched for gender, age, and years of education.

Results: The network-based statistic (NBS) on DMN-DAN-FPCN connectivity of these groups revealed statistically significant (p NBS2.58) reductions in within-DMN, within-FPCN, DMN-DAN, and DMN-FPCN connectivity of the TBI group over healthy controls. Importantly, such disruptions occurred prominently in between-network connectivity. Subsequent analyses further exhibited the disrupted connectivity patterns of the chronic TBI group occurring preferentially in long-range and inter-hemispheric connectivity of DMN-DAN-FPCN. Most importantly, graph-theoretic analysis demonstrated relative reductions in global, local and cost efficiency (p<.05) as a consequence of the network disruption patterns in the TBI group.

Conclusion: Our findings suggest that assessing multiple networks-of-interest simultaneously will allow us to better understand deficits in goal-directed cognition and other higher order cognitive phenomena in chronic TBI. Future research will be needed to better understand the behavioral consequences related to these network disruptions.

Keywords: Attention network; Default network; Fronto-parietal control network; Functional connectivity; Goal-directed cognition; Graph theory; TBI; fMRI.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Attention Deficit Disorder with Hyperactivity* / diagnostic imaging
  • Attention Deficit Disorder with Hyperactivity* / etiology
  • Attention Deficit Disorder with Hyperactivity* / pathology
  • Brain Injuries, Traumatic / complications*
  • Brain Mapping*
  • Chronic Disease
  • Female
  • Frontal Lobe / diagnostic imaging
  • Frontal Lobe / pathology*
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Models, Neurological
  • Nerve Net / diagnostic imaging
  • Nerve Net / pathology*
  • Neuropsychological Tests
  • Parietal Lobe / diagnostic imaging
  • Parietal Lobe / pathology*
  • Psychiatric Status Rating Scales
  • Statistics, Nonparametric
  • Young Adult