Obesity Impacts Fever and Sickness Behavior During Acute Systemic Inflammation

Physiology (Bethesda). 2016 Mar;31(2):117-30. doi: 10.1152/physiol.00049.2015.


Obesity is reaching dramatic proportions in humans and is associated with a higher risk for cardiovascular disease, diabetes, and cognitive alterations, and a higher mortality during infection and inflammation. The focus of the present review is on the influence of obesity on the presentation of fever, sickness behavior, and inflammatory responses during acute systemic inflammation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Acute Disease
  • Animals
  • Behavior, Animal / physiology*
  • Brain / physiopathology*
  • Humans
  • Illness Behavior / physiology*
  • Inflammation / complications
  • Inflammation / physiopathology*
  • Obesity / complications*
  • Obesity / physiopathology*