Loss of Merlin/NF2 protects pancreatic β-cells from apoptosis by inhibiting LATS2

Cell Death Dis. 2016 Feb 18;7(2):e2107. doi: 10.1038/cddis.2016.21.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Apoptosis*
  • Caspase 3 / metabolism
  • Humans
  • Insulin-Secreting Cells / cytology
  • Insulin-Secreting Cells / metabolism
  • Mechanistic Target of Rapamycin Complex 1
  • Multiprotein Complexes / metabolism
  • Neurofibromin 2 / antagonists & inhibitors
  • Neurofibromin 2 / genetics
  • Neurofibromin 2 / metabolism*
  • Poly(ADP-ribose) Polymerases / metabolism
  • Protein-Serine-Threonine Kinases / antagonists & inhibitors
  • Protein-Serine-Threonine Kinases / metabolism*
  • RNA Interference
  • RNA, Small Interfering / metabolism
  • Signal Transduction
  • TOR Serine-Threonine Kinases / metabolism
  • Tumor Suppressor Proteins / antagonists & inhibitors
  • Tumor Suppressor Proteins / metabolism*

Substances

  • Multiprotein Complexes
  • Neurofibromin 2
  • RNA, Small Interfering
  • Tumor Suppressor Proteins
  • Poly(ADP-ribose) Polymerases
  • TOR Serine-Threonine Kinases
  • LATS2 protein, human
  • Mechanistic Target of Rapamycin Complex 1
  • Protein-Serine-Threonine Kinases
  • Caspase 3