[Treatment of pathological laughing with amitriptyline]

Rinsho Shinkeigaku. 1989 Sep;29(9):1183-5.
[Article in Japanese]


We investigated the efficacy of amitriptyline in seven patients with pathological laughing caused by cerebrovascular diseases. In a double-blind placebo-controlled cross-over trial comparing amitriptyline with placebo, 5 of these 7 patients were judged to have shown improvement with amitriptyline, and 1 patient improved with placebo. This difference was statistically significant. No significant side effect of amitriptyline was observed. There was no significant change between amitriptyline and placebo in both self-rating depression scale and minimental state test score. These results suggested that amitriptyline was useful in treating pathological laughing.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial
  • English Abstract

MeSH terms

  • Aged
  • Amitriptyline / therapeutic use*
  • Cerebrovascular Disorders / physiopathology*
  • Clinical Trials as Topic
  • Double-Blind Method
  • Female
  • Humans
  • Laughter*
  • Male
  • Middle Aged


  • Amitriptyline