Pulmonary manifestations of the collagen vascular diseases

Clin Chest Med. 1989 Dec;10(4):677-722.


The collagen vascular diseases are a heterogeneous group of immunologically mediated inflammatory disorders. The organs and tissues that compose the respiratory system are frequently affected by these diseases. Potential targets of the inflammation and injury include the lung parenchyma, tracheobronchial tree, pulmonary vasculature, pleura, larynx, and respiratory muscles. In this article, the spectrum of respiratory disease caused by systemic lupus erythematosus, rheumatoid arthritis, scleroderma, polymyositis/dermatomyositis, mixed connective tissue disease, ankylosing spondylitis, relapsing polychondritis, and Sjögren's syndrome is reviewed. Where appropriate, therapeutic options are discussed.

Publication types

  • Review

MeSH terms

  • Arthritis, Rheumatoid / complications
  • Bronchoalveolar Lavage Fluid / cytology
  • Collagen Diseases / complications*
  • Collagen Diseases / diagnostic imaging
  • Humans
  • Lung Diseases / etiology*
  • Lung Diseases / pathology
  • Lupus Erythematosus, Systemic / complications
  • Lupus Erythematosus, Systemic / pathology
  • Polychondritis, Relapsing / complications
  • Radionuclide Imaging
  • Scleroderma, Systemic / complications
  • Sjogren's Syndrome / complications
  • Sjogren's Syndrome / diagnostic imaging
  • Spondylitis, Ankylosing / complications